… ;Cx43 fx/fx ;Cx37 −/− mice, we tested our method on lymphatic valves displaying a wide range
… -leak or valve stiffness in the absence of pressure measurement/control. Without pressure …

… we examined EC polarization in the presence and absence of Cx37. Because we thought that
… The Cx37-null mouse lacks the aspect of abnormal mechanotransduction that is present in …

… Cx37 − / − mice show perturbed lymphatic valve formation resulting in virtual absence of
valves and significant lymphedema in adults (22, 23). Mice with a lymphatic EC-specific ablation …

… , Cx37 is growth suppressive at cell densities where gap junction channels cannot form due
to lack of cell… Cardiac malformation in neonatal mice lacking connexin43. Science. 1995;267(…

… Cx37 is not changed, suggesting posttranslational effects. It was speculated that the lack of
… , thus leading exclusively to formation of Cx37 that may be less stable than heteromers (436)…

… connexin37 and connexin43 (both required for normal valve development) around reorientating
valve-forming cells and produced deficient valve… because of a lack of specific antibodies, …

… However, in mice lacking Cx43, AM had no effect on lymphatic tail velocity. … Cx37 is notably
absent from the lymphatic vessels in the heart in both murine and human tissue, making mice …

… to venous valves (17). Genetic ablation of Cx37 and Cx43 leads to lymphatic valve malforma…
either knockout or wildtype mice, thus a lack of regional protein expression may explain the …

… the focal appearance of large-caliber AVMs that lack clear arterial or venous identity 60,
65 . … , and Cx37 is a particularly potent inhibitor of cell cycle progression 81 . Cx37 directly …

… formation include the gap junction genes Gja4 (Cx37), Gja1 (Cx43), and Gjc2 (Cx47). These
… patterns around the valves, and deletion of Cx37 results in the absence of venous valves. …